| Name | Description | Molecular Function | Cellular Component | Biological Process |
|---|
| Insulin R |
Receptor tyrosine kinase |
insulin-like growth factor receptor binding,
PTB domain binding,
metal ion binding,
GTP binding,
insulin receptor substrate binding,
ATP binding,
protein complex binding,
phosphoinositide 3-kinase binding,
insulin-like growth factor II binding,
receptor signaling protein tyrosine kinase activity,
insulin binding,
3-phosphoinositide-dependent protein kinase binding,
lipoic acid binding,
protein phosphatase binding,
insulin-like growth factor I binding,
insulin receptor activity,
SH2 domain binding |
microsome,
cytosol,
caveola,
insulin receptor complex,
soluble fraction,
endosome,
synapse,
nucleus,
endosome membrane |
positive regulation of glycolysis,
regulation of embryonic development,
fat cell differentiation,
response to activity,
heart morphogenesis,
positive regulation of cell migration,
regulation of hydrogen peroxide metabolic process,
carbohydrate metabolic process,
response to tumor necrosis factor,
protein amino acid autophosphorylation,
activation of MAPK activity,
response to glucocorticoid stimulus,
positive regulation of respiratory burst,
response to manganese ion,
activation of protein kinase B activity,
positive regulation of DNA replication,
positive regulation of protein amino acid phosphorylation,
positive regulation of cell proliferation,
negative regulation of transporter activity,
positive regulation of glycoprotein biosynthetic process,
glucose homeostasis,
positive regulation of nitric oxide biosynthetic process,
transformation of host cell by virus,
response to protein stimulus,
regulation of gene-specific transcription,
response to estradiol stimulus,
protein heterotetramerization,
response to glucose stimulus,
positive regulation of protein kinase B signaling cascade,
response to testosterone stimulus,
negative regulation of gene expression,
positive regulation of glycogen biosynthetic process,
positive regulation of mitosis,
peptidyl-tyrosine phosphorylation,
response to vitamin D,
positive regulation of glucose import,
male sex determination,
response to ethanol,
negative regulation of protein amino acid phosphorylation,
G-protein coupled receptor protein signaling pathway,
positive regulation of MAPKKK cascade,
exocrine pancreas development,
positive regulation of developmental growth |
| Insulin receptor substrate 2 |
Adaptor molecule |
signal transducer activity,
receptor activity,
protein kinase binding |
plasma membrane,
cytosol |
positive regulation of mesenchymal cell proliferation,
positive regulation of cell migration,
positive regulation of fatty acid beta-oxidation,
mammary gland development,
glucose metabolic process,
cell proliferation,
brain development,
negative regulation of kinase activity,
positive regulation of insulin secretion,
positive regulation of B cell proliferation,
response to glucose stimulus,
lipid homeostasis,
positive regulation of glycogen biosynthetic process,
negative regulation of plasma membrane long-chain fatty acid transport,
negative regulation of B cell apoptosis,
insulin receptor signaling pathway,
positive regulation of glucose import |
| Insulin receptor substrate 1 |
After phosphorylation by insulin receptor binds to various cellular proteins containing SH2 domains. |
protein kinase C binding,
insulin-like growth factor receptor binding,
insulin receptor binding,
transmembrane receptor protein tyrosine kinase docking protein activity,
phosphoinositide 3-kinase binding,
insulin-like growth factor receptor activity,
SH2 domain binding |
microsome,
cytosol,
caveola,
insulin receptor complex,
nucleus |
positive regulation of mesenchymal cell proliferation,
negative regulation of somatostatin secretion,
positive regulation of insulin receptor signaling pathway,
positive regulation of cell migration,
positive regulation of fatty acid beta-oxidation,
negative regulation of insulin secretion,
mammary gland development,
protein heterooligomerization,
positive regulation of phosphoinositide 3-kinase activity,
negative regulation of insulin receptor signaling pathway,
glucose homeostasis,
phosphoinositide 3-kinase cascade,
protein kinase B signaling cascade,
positive regulation of glycogen biosynthetic process,
insulin receptor signaling pathway,
positive regulation of glucose import,
positive regulation of phosphorylation,
positive regulation of glucagon secretion |
| Insulin receptor substrate 4 |
Cell cycle control protein |
insulin receptor binding,
SH3/SH2 adaptor activity |
plasma membrane |
|
| Insulin receptor tyrosine kinase substrate |
unclassified |
cytoskeletal adaptor activity,
actin binding,
SH3 domain binding |
|
signal transduction,
filopodium assembly |
